Senior Scientist - Biotherapeutics Polyreactivity & Developability Job at Bristol-Myers Squibb, San Diego, CA

  • Bristol-Myers Squibb
  • San Diego, CA

Job Description

Working with Us Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: . When you join BMS, you are joining a diverse, high-achieving team united by a common mission. The Discovery Biotherapeutics team at BMS seeks to understand the structure and function of complex molecules such as bispecific antibodies, antibody drug conjugates and endogenous proteins in order to optimize their utility as therapeutic agents. We collaborate with biology and translational scientists imbedded in the Thematic Research Centers in order to prosecute Targets and Biological pathways with disease modifying potential. By using a blend of internal and external technologies and capabilities, we work to discover and deliver first-in-class as well as best-in-class molecules that warrant clinical evaluation for patient benefit. Here, you'll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You'll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma. Senior Scientist Biotherapeutics Developability Bristol Myers Squibb is seeking a highly motivated and innovative Senior Scientist with demonstrated expertise in antibody developability and characterization of monoclonal antibodies, bi/multispecifics, Fc-fusion proteins, and antibody-drug conjugates (ADCs) to join our Discovery Biotherapeutics team. Responsibilities will include a range of activities related to antibody and therapeutic protein developability characterization including but not limited to high-throughput plate-based screening for polyreactivity, analytical chromatographic methods for hydrophobicity, molecule integrity and pharmacokinetic prediction, and high throughput assays for manufacturability. This role will work in close collaboration with the protein engineering and characterization teams to test, design and optimize early to late-stage therapeutics to accelerate biotherapeutic discovery. The ideal candidate should also have knowledge/experience in protein chemistry, protein engineering, in silico modeling and prediction, and generation of large high-quality datasets to aid in generating training datasets for AI/ML guided therapeutic design. Responsibilities:

  • Develop and perform plate-based methodologies to address biotherapeutic polyreactivity for a range of modalities including antibodies, bi-/multi-specific antibodies, Fc-fusion, VHH, ADCs, etc.
  • Serve as the lead and point of contact on antibody developability, managing requests, performing diverse assays, analyzing, communicating results, and cataloging of all data in databases.
  • Execute on early to late-stage characterization for the developability of biotherapeutics including biophysical and bioanalytical methods involving plate-based assays, chromatographic methods, stability and aggregation propensities, structural properties, etc. with the goal of feeding training sets for ML and utilizing the output for improved therapeutic design.
  • Demonstrate significant expertise in biophysical and bioanalytical characterization of large molecules to address hydrophobicity, polyreactivity, polyspecificity, self/cross-interaction, colloidal and conformational stability, aggregation propensity, chemical stability, half-life (PK) predictors, and ADC toxicology predictors.
  • Proactively identify liabilities for antibody developability, manufacturability or pharmacokinetics and work with protein engineering teams to guide design and optimization using sequence and computational prediction tools.
  • Serve as the point of contact on antibody polyspecificity, managing requests and communicating results.
  • Collaborate with multiple project teams in all disease areas to advise on key metrics of antibody developability, polyreactivity, manufacturability, and stability.
  • Collaborate with our late-stage manufacturability scientists to support characterization of forced degradation studies.
  • Develop new and innovative approaches and methodologies to accelerate early developability/manufacturability testing through miniaturization, increasing throughput and automating assay and data capture.
  • Collaborate with the automation engineers for the high-throughput scaling of established assays.
  • Prepare and present data and updates to project and functional teams, official reports and SOPs for internal and external purposes, internal documents/reports for regulatory filings.
  • Stay current on biophysical and biochemical technologies and relevant literature, recognize risks and propose contingency plans.
  • Collaborate with multiple teams across the organization, to support and share methodologies, align on efforts, and harmonize experimentation.
  • Manage lab/equipment organization and maintenance.
Basic Qualifications: Bachelor's Degree with 7+ years of academic / industry experience Or Master's Degree with 5+ years of academic / industry experience Or PhD with 2+ years of academic /industry experience Preferred Qualifications:
  • PhD in Biophysics, Biochemistry or related discipline with 2 years of relevant experience or MS with at least 5 years of work experience. Work experience is ideally in a biotech/pharma/industry environment.
  • Proven track record and hands-on experience with biotherapeutic modalities and modern developability/manufacturability assays, methods and workflows.
  • Expertise in high throughput plate-based assays including, but not limited to, ELISA, fluorescence, FLISA, HTRF, Flow cytometric, AlphaELISA, etc.
  • Extensive experience in analytical liquid chromatograph (HIC, AnSEC, FcRn, Heparin Sulfate, RP, SMAC etc.).
  • Demonstrated experience in antibody colloidal stability/self-interaction analysis (e.g. SI-BLI, AC-SINS, kD, viscosity, etc.).
  • Experience in antibody conformational/thermal stability (e.g., Tm/Tagg, DSF, DSC, etc.).
  • Experience in light scattering methodologies for analysis of biologic modalities and accelerated stability (DLS, SLS, SEC-MALS, Mass Photometry, etc.).
  • Experience in biotherapeutic aggregation, solubility, and clipping analysis (AnSEC, Mass Photometry, PEG, CE-SDS, etc.).
  • Deep understanding of antibody polyreactivity, stability, solubility, aggregation potential, chemical and other manufacturing liabilities, immunogenicity.
  • Advanced knowledge of high throughput developability and pharmacokinetics including assessment and mitigation strategies.
  • Familiarity with biotherapeutic manufacturability/accelerated stability testing methods including forced degradation, oxidation, isomerization, deamidation, etc.
  • Prior experience with antibody biophysical characterization and binding assays of complex biologics (SPR, BLI, ITC, MST, etc.).
  • Deep knowledge in antibody sequence, sequence motifs, and sequence liabilities.
  • Broad familiarity with sequence- and structure-based protein modeling tools.
  • Experience with high-throughput screening and automated liquid handling.
  • Experience with large data generation, analysis and capture (e.g., LIMS systems).
  • Exceptional organizational & time management skills, and attention to detail.
  • Strong written and oral communication skills are essential.
Skills/Knowledge in one or more of the following areas are a plus:
  • In silico modeling and prediction: homology modeling (e.g., MOE, Schrodinger, etc.), correlation of structure-based calculations/properties with experimental data, structure-activity relationship, etc.
  • Knowledge/experience in protein and antibody engineering, structure, and design. Collaborate with the protein engineering teams to aid in the design of molecules with improved properties.
  • Knowledge of antibody-based and computational databases for analysis and design of sequences (e.g., IMGT, OAS, AlphaFold2, etc.).
  • Experience in aspects of structural biology (x-ray crystallography, cyro-EM, nsEM, NMR).
  • Experience with programming languages like python, R, etc. is a plus.
For California Sites - The starting compensation for this job is a range from $109,000 - $150,700, plus incentive cash and stock opportunities (based on eligibility). The starting pay takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation is decided based on demonstrated experience. For more on benefits, please visit our BMS Careers site. Eligibility for specific benefits listed in our careers site may vary based on the job and location. If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. Uniquely Interesting Work, Life-changing Careers With a single vision as inspiring as Transforming patients' lives through science™ , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues. On-site Protocol BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role: Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function. BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to . Visit eeo -accessibility to access our complete Equal Employment Opportunity statement. BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters. BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area. Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Job Tags

Work experience placement, Remote job, Shift work,

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