Senior Scientist, Chemistry Job at Sarepta Therapeutics, Inc., Cambridge, MA

N0Q4YXErMVJ1a2tBMFFpTHZYemJMTHNo
  • Sarepta Therapeutics, Inc.
  • Cambridge, MA

Job Description

The RNA Research group at Sarepta Therapeutics is seeking a talented, motivated, and experienced scientist to join the dynamic and fast-paced chemistry team located in Cambridge, MA. The successful candidate will work on our PMO oligonucleotide platform and discovery research on improved delivery of oligonucleotides as well as manage collaborations and CROs as needed. This position will work closely with Discovery Biology, Translational Sciences, Business Development and Legal teams to implement new drug discovery programs and advance next generation of RNA therapeutics.

Primary Responsibilities Include:
  • Design and conduct novel oligonucleotide conjugates synthesis, purification, and characterization; Apply state-of-the-art delivery methods to achieve in vivo proof of concept; Develop efficient and scalable synthetic methods and routes.
  • Develop and utilize innovative synthetic, medicinal chemistry and/or chemical biology problem solving skills coupled with analysis of diverse data sets to build structure-activity relationships.
  • Act as key member of a multidisciplinary RNA research team, assisting with development of project strategy, and analysis and communication of complex data.
  • Serves as an in-house oligonucleotide and delivery chemistry expert.
  • Drive the writing of technical reports to support patent applications and manuscript preparations.
  • Coordinate and manage collaborations and CRO operations to ensure deliverables meet project needs.
  • Organize workstreams and complete individual and team objectives to maintain project timelines.
  • Supervise and mentor junior staff.

Desired Education and Skills:
  • The ideal candidate will have a PhD in organic chemistry, biochemistry, or related fields with 4+ years of relevant post-doctoral or industry experience; or M.S. with 8+ years of experience.
  • Strong experience in organic chemistry and multi-step organic synthesis is a must; Hands-on experience with manual and automated systems for solid-phase synthesis of peptides and nucleic acids is essential for this role.
  • Previous experience in the design, chemical optimization, and formulation/delivery of peptides and/or oligonucleotide therapeutics is highly desirable.
  • Experience with using analytical techniques/instrumentation for peptides and/or oligonucleotides purification and characterization such as Reverse Phase (HPLC/UPLC), MALDI-TOF and Liquid Chromatography Mass Spectrometry (LC-MS) is a plus.
  • Track record with the ability to execute multiple concurrent research projects within a cross-functional team environment.
  • Solid written and oral communication skills, enthusiasm, integrity, self-motivation, strong interpersonal skills, and attention to detail are necessary.

#LI-TD1

#LI-Onsite

This position requires work on site at one of Sarepta's facilities in the United States.

The targeted salary range for this position is $120,000 - $150,000 per year. Sarepta is making a good faith effort to be transparent and accurate around our hiring ranges. The salary offer is commensurate with Sarepta's compensation philosophy and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity.

Candidates must be authorized to work in the U.S.

Sarepta Therapeutics offers a competitive compensation and benefit package.

Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.

Job Tags

Similar Jobs

Nesco Resource

Maintenance Technician Job at Nesco Resource

 ...Description : Maintenance Technician is responsible for identifying and repairing problems in assembly equipment. Duties/Responsibilities...  ...schedules and perform P.M. for all equipment # Performs building maintenance, and installation of electrical, plumbing, etc.... 

Luytens Technology Solutions Pvt. Ltd.

Cloud DevOps Engineer Job at Luytens Technology Solutions Pvt. Ltd.

 ...Job Description Job Description Role: Cloud DevOps Engineer Location: Dallas or Miami Onsite ( Hybrid)& Responsibilities: Collaboration with Application Teams to deliver AWS Deployment Architecture Diagrams Identification and refinement of Jira Backlog... 

Tufts Medicine Care at Home

Wound Care Ostomy Nurse, RN - Home Health Job at Tufts Medicine Care at Home

 ...Foundation is now the future of Tufts Medicine Care at Home. Tufts Medicine Care at...  ...in the assessment and treatment of skin, wound, pressure ulcers, and ostomies for inpatients...  ...care team. Works closely with the nurse educators and other nursing leaders to proactively... 

Pearson Education

Massachusetts Scoring Assistant - Biology Job at Pearson Education

 ...and personalized learning at scale. We believe that wherever learning flourishes so do people. The Evaluation Systems group of Pearson offers dynamic teacher licensing and performance assessment solutions. Our custom teacher licensure testing programs are 100 percent... 

Thompson Machinery

Rental Heavy Equipment Truck Driver Job at Thompson Machinery

Truck Driver Heavy EquipmentJOB PROFILEOperates Class 7 or higher sized trucks requiring current Commercial Drivers License (CDL) in good standing for appropriate vehicle classifications. Trucks will include day-cab tractors pulling flat-bed or lowboy trailers...